The indicated cells were then orthotopically implanted into 6 week old female NOD/SCID mice, and then the tumors were removed after reaching a volume of 300 mm3 (Figure 4F‐a).[45] The results showed that overexpression of CUL4B could promote the tumor growth rate, while CUL4B knockout significantly reduced the tumor growth rate (Figure S4D, Supporting Information 1). The gene discussed is CUL4B; the disease is neoplasm.