CUL4B and neoplasm: The biological effects elicited by the EMT program are not only existed in cancer metastasis, as the EMT of human mammary epithelial cells can produce cells with properties associated with mammary epithelial stem cells, including the expression of stem cell markers and an increased ability to form mammospheres.[33, 77] Moreover, several signaling pathways link EMT to self‐renewal and tumor formation.[78, 79, 80, 81, 82] Therefore, it is unclear whether CUL4B affects the CSC state through participating in the EMT process.