These findings may shed light on how transcription factors enable the initial steps of metastasis, stimulation of EMT, physical dissemination, and finally development of a CSC phenotype.[83] Notably, CRL4B was found positioned as a major transcriptional hub for regulating breast cancer progression, supporting the pursuit of CUL4B as a potential therapeutic target of breast cancer. This evidence concerns the gene CUL4B and breast carcinoma.