Collectively, these results suggest that CRL4B is a key node within the EMT epigenetic regulation network which is positively regulated by EMT‐promoting pathways while negatively regulated by the estrogen signaling pathway, and a reciprocal feedback regulatory loop exists between CRL4B/NuRD(MTA1) and the E2/ERα‐GATA3/NuRD(MTA3) axis in controlling EMT and progression of breast cancer (Figure 6L). The gene discussed is ESR1; the disease is breast cancer.