In addition, analysis of METABRIC public datasets,[57] obtained from cBioPortal,[57, 58] indicated that CUL4B expression levels were positively correlated with several molecular subtypes of breast cancer, including the Luminal, Her2, and Basal subtypes, while ERα expression showed the opposite trend (Figure S8A, Supporting Information 1). This evidence concerns the gene ERBB2 and breast cancer.