During the progression of EMT, transcription factors including Snail, Slug, ZEB1, ZEB2, Twist, Twist2, and E47 recruit various DNA/histone modification complexes to repress E‐cadherin and promote EMT.[23] The coimmunoprecipitation assays showed that Snail, Slug, ZEB1, ZEB2, Twist, and Twist2 could interact with CUL4B, indicating that CUL4B is a key node for multiple tumor metastasis pathways and epigenetic regulatory networks (Figure5A). This evidence concerns the gene TCF3 and neoplasm.