MTA1 and MTA2 have emerged as one of the most upregulated genes in several human cancers, including breast and endometrial cancer, whereas MTA3 may be downregulated.[65] CRL4B directly interacted with MTA1/2 instead of MTA3, indicating that CRL4B is selective for the subunits of the NuRD complex. This evidence concerns the gene MTA2 and cancer.