In RCC, the co-occurrence of APC and KRAS and the mutually exclusive relationship of BRAF with APC and KRAS further indicated a potential relationship with CIN and CIMP (Issa, 2008).The different molecular mechanisms of RCC and LCC suggest that they may require different therapeutic approaches and prognoses. This evidence concerns the gene KRAS and leukoencephalopathy with calcifications and cysts.