In RCC, the co-occurrence of APC and KRAS and the mutually exclusive relationship of BRAF with APC and KRAS further indicated a potential relationship with CIN and CIMP (Issa, 2008).The different molecular mechanisms of RCC and LCC suggest that they may require different therapeutic approaches and prognoses. The gene discussed is APC; the disease is leukoencephalopathy with calcifications and cysts.