Yamakita et al. (2019) used migration and wound healing tests to confirm that GBP1 may enhance the aggressiveness of lung adenocarcinoma by promoting cell movement. However, GBP1 inhibits the proliferation, migration, and invasion of CRC cells by mediating the anti-tumor effect of IFN-γ (Britzen-Laurent et al., 2013). Low GBP6 expression has been confirmed in tongue squamous cell carcinoma and is related to the poor prognosis of these patients (Liu et al., 2020). There are no reports on the role of GBP-2 in PAAD to date. This evidence concerns the gene GBP1 and colorectal carcinoma.