CD4 and neoplasm: Activated CD4 memory T cells were involved autoimmune processes, M1 macrophages functioned in proinflammatory, microbicidal, and tumor resistance processes, and resting dendritic cells induced tumor immune tolerance through the receipt of immunosuppression signals (Adema, 2009; Cheng et al., 2019; Seledtsov & Seledtsova, 2019).