HSPA5 and central nervous system cancer: By real-time quantitative PCR detection, compared with normal brain tissue (0.96 ± 0.28), the expression of mRNA HSPA5 in WHO II gliomas and WHO III/IV glioma tissue both increased significantly (1.25 ± 0.32,1.85 ± 0.70), and the differences were statistically significant (P < 0.05, Fig. 6).