Compared with normal brain tissue (0.60 ± 0.28), the expression of mRNA MTPN in WHO II gliomas and WHO III/IV glioma tissues also increased greatly (0.95 ± 0.19,1.01 ± 0.39), and the difference was statistically significant (P < 0.05, Fig. 6). Here, MTPN is linked to central nervous system cancer.