Ever smoking was associated with microsatellite instability (MSI)-high and microsatellite stability (MSS)/MSI-low CRC, but the association was significantly stronger for ∼50% for MSI-high CRC [54], and cigarette smoking was also associated with the CIMP-positive and BRAF mutation-positive colorectal-cancer subtypes [55]. Here, BRAF is linked to colorectal carcinoma.