Moreover, 200 mg/kg BW ALA significantly decreased the hepatic levels of NLRP3 inflammasome activation‐related proteins NLRP3, caspase‐1, and interleukin‐1β expression by 40.0%, 60.1%, and 24.5%, respectively, in T2DM rats. The gene discussed is NLRP3; the disease is type 2 diabetes mellitus.