In their research, it was discovered that there was imbalance of Treg and Th17 ratio in peripheral blood of MEKKK2 systematic knockout mice and MEKKK3 conditional knockout mice, which could make EAE mice more susceptible to disease and accumulate more antigen‐specific Th17 in the central nervous system that might be related to the imbalance of T‐cell differentiation, suggesting that the activation of MEK2 and MEKK3 signaling pathways in T cells plays an important regulatory role in inflammation and autoimmune diseases. Here, MAP4K3 is linked to autoimmune disease.