In accordance to this study, the heterogeneity of CD8+ T cell transcription profiles from 51 ECs cannot be explained by differences in age, gender, race and ethnicity of individuals, as well as presence of protective alleles HLA-B*57/B*27/B*5801, the duration of HIV infection, viral load, the ratio of CD4+ / CD8+ cells, total CD4+ counts, the neutralizing breadth of HIV-specific antibodies, and the breadth and magnitude of HIV-specific cytotoxic response [38]. This evidence concerns the gene CD4 and HIV infectious disease.