ESR1 and breast cancer: Further, the double-targeted nanocarrier, Quercetin-3′3-dithiodipropionic acid-Astragalus polysaccharides-Folic acid (QDAF), was synthesized and self-assembled into a neoteric nano-targeted delivery strategy, named nano-pomegranates, to effectively suppress MDR in estrogen receptor α (ERα)-positive breast cancer.