Moreover, morin hydrate reversed the acquired resistance of cisplatin-resistant hepatocellular cancer HepG2DR cells by impairing PARP-1/HMGB1-dependent autophagy; indeed, PARP-1 autophagy appears to be regulated by the PARylation of HMGB1 [51]. The gene discussed is HMGB1; the disease is hepatocellular carcinoma.