(3) Hypomethylation of the MIR487B promoter with increasing PA, but hypermethylation with increasing C20:1, EDA, and DGLA, is in agreement with its previously documented adverse effect of MIR487B on insulin signaling and upregulation in hypertension in vivo in a rat model, validated in human cultured cells (Nossent et al., 2013). The gene discussed is INS; the disease is hypertensive disorder.