Attenuated sporozoite-induced sterile immunity requires a CD8 T cell response targeting pre-erythrocytic stage antigens (8–12) of which a limited number of antigens targeting the liver stage of malaria have been tested in humans including CSP, TRAP, LSA-1, LSA-3, EXP-1, STARP, and cell-traversal protein for ookinetes and sporozoites (27). This evidence concerns the gene CD8A and malaria.