Collectively, longitudinal follow up of cohort one during convalescence revealed that while the overall panlymphopenia resolved, infected individuals maintained aberrations in certain lymphocyte subset compartments; specifically, persistently reduced naïve CD4+ and CD8+ T cells, in addition to expanded effector CD8+ T cells and activated CD4+ and CD8+ T cells at a median of 68 days following infection. The gene discussed is CD4; the disease is infection.