In summary, it was previously reported that CXCL8 acts as a key multifunctional chemokine to modulate tumor cells for proliferation, invasion, migration, and as a chemotactic factor for neutrophils, MDSCs and monocytes, which served as immunosuppressive components in cancer-bearing hosts and led to a poor prognosis. The gene discussed is CXCL8; the disease is neoplasm.