Then, we used a small-molecule pharmacologic CXCR1/2 antagonist to block the CXCL8 receptor in murine tumor models established with CT26 or MC38 CRC cell to determine the effect of tumor-specific CXCL8-CXCR1/2 signaling impact on tumor behavior. The gene discussed is CXCL8; the disease is colorectal carcinoma.