TREM2 and Alzheimer disease: Interestingly, microglia that populate plaques in AD, termed disease-associated microglia (DAMs) (136), appear to transition from an initial glycolytic, reactive state into an apparent hypometabolic state with significantly altered mTOR activity, which is possibly related to alterations in the phagocytic and/or lipid-sensing function of the AD risk-associated triggering receptor on myeloid cells 2 (TREM2) (130, 131, 134).