IGFBP7 and obesity due to melanocortin 4 receptor deficiency: Specifically, they found that obesity-induced insulin resistance does not induce pro-inflammatory activation of liver TRMs, but rather produce insulin-like growth factor-binding protein 7 (IGFBP7) which acts as a non-inflammatory immune cell-derived metabolite to induce lipogenesis and gluconeogenesis via insulin receptor signaling.