We assessed the effect of latent CMV infection on the CD8+ T-cell pool of all healthy individuals, by performing a cluster analysis (tSNE) based on memory T-cell markers CD27, CCR7, CD95, CD45RO, and CXCR3, and senescence-associated T-cell markers CD57 and KLRG-1, known to be altered in CMV infection (56). This evidence concerns the gene CD27 and cytomegalovirus infection.