Most notably, CDK4/6i increases expression of antigen presenting genes (H2d1, H2k1, B2m, Erap1, Tap1, Tap2) and surface expression of MHC I and MHC II in several mouse and human breast and colon carcinoma pre-clinical models (108, 109, 113) (Figure 3). Here, CDK4 is linked to colon carcinoma.