Immunostimulatory DAMPs include a release of endoplasmatic reticulum proteins like calreticulin and heat shock proteins (HSP), the toll-like receptor (TLR) 4 and TLR9 agonist high mobility group box 1 (HMGB1) and ATP, leading to DC recruitment and activation at the site of tumor cell death (50). This evidence concerns the gene HMGB1 and neoplasm.