Several prerequisites for a successful antitumor immune response have been identified: i) The availability of TAAs in a sufficiently immunogenic setting to trigger phagocytosis and activate DCs; ii) an efficient antigen presentation with co-stimulatory signals to successfully cross-prime CD8+ cytotoxic T cells; and iii) a cytotoxic T cell response that overcomes inhibitory signals from the tumor and TME. Here, CD8A is linked to neoplasm.