CD4 and neoplasm: Furthermore, an upregulation of the chemotactic C-C chemokine ligand (CCL)5 and CXC-ligand (CXCL)16 pathway and an increased infiltration of CD8+ T cells and Natural Killer (NK) cells into the tumor were observed in HCC patients undergoing Yttrium-90 radioembolization, along with an increase of APCs and CD4+ and CD8+ cells in peripheral blood (113).