Th17 cells have also been associated with tumor progression in oral cancer (39), as well as Tregs, which have been found increased not only in the oral tissue, but also in peripheral blood (40, 41), expressing CTLA-4+, HLA-DR+ and granzyme B+ (42) and inhibiting IFN-γ, and promoting IL-10 and TGF-β secretion (43, 44). The gene discussed is CTLA4; the disease is lip and oral cavity carcinoma.