CCR4 and melanoma: Our previous data reveled a significant association between Th2-like Tregs with colorectal cancer and melanoma, however despite the fact we observed higher percentages of Th2-like Tregs in OSCC in comparison with control samples, Th-like subsets overall did not cover the majority of the memory Treg population as it occurs in peripheral blood due to high CCR4 expression in circulation (15).