Our previous data reveled a significant association between Th2-like Tregs with colorectal cancer and melanoma, however despite the fact we observed higher percentages of Th2-like Tregs in OSCC in comparison with control samples, Th-like subsets overall did not cover the majority of the memory Treg population as it occurs in peripheral blood due to high CCR4 expression in circulation (15). Here, CCR4 is linked to colorectal cancer.