Our novel method for serial home-based sampling of NLF was applied to 10 CF patients carrying a G551D mutation and shows significant declines of IL-1β, 6 and 8 (2.27, 1.13 and 3.53-fold, respectively, p<0.05) during the first 3 months of treatment with ivacaftor. Here, IL1B is linked to cystic fibrosis.