Overexpression of master pro-inflammatory cytokine tumor necrosis factor alpha (TNF-α) plays a crucial role in the pathogenesis of autoimmune disorders such as rheumatoid arthritis (RA), psoriasis (PsO), ankylosing spondylitis (AS), ulcerative colitis (UC), and crohn’s disease (CD) (2). The gene discussed is TNF; the disease is autoimmune disease.