Overexpression of master pro-inflammatory cytokine tumor necrosis factor alpha (TNF-α) plays a crucial role in the pathogenesis of autoimmune disorders such as rheumatoid arthritis (RA), psoriasis (PsO), ankylosing spondylitis (AS), ulcerative colitis (UC), and crohn’s disease (CD) (2). This evidence concerns the gene TNF and Crohn disease.