Additionally, it provides a powerful and promising strategy (targeting Notch signaling) to combat infection and inflammation during SARS-CoV-2 infection. A large-scale study should be performed to look at the level of ACE2 in a large number of blood samples from patients on various treatment options in order to establish a true conclusion about the effect of anti-TNF-α on ACE2 level in patients. Here, TNF is linked to infection.