Based on the studies above, we hypothesize that CTRP1 may play a role in modulating cardiac remodelling post MI, and we herein used CTRP1 global knockout (KO) mice and recombinant CTRP1 protein to elucidate the functional role of CTRP1 in cardiac remodelling post MI. This evidence concerns the gene C1QTNF1 and myocardial infarction.