BM localization of the more functional NK KLRG1− subtypes is impaired in MM by altering the chemokine microenvironment (increasing chemokine [CXC] ligand 9 [CXCL9] and CXCL10 and reducing CXCL12 expression in BM) in a mouse tumor model of an early cancer growth stage (88). This evidence concerns the gene CXCL12 and neoplasm.