Antibodies that use the DVD-Ig platform are ABT122 (IL-7×TNF-α), which is used to treat patients with rheumatoid arthritis (RA) who have experienced an inadequate response to methotrexate (47); and ABT165 (Delta-like ligand 4, DLL4×VEGF) which can effectively and significantly inhibit tumor growth in U87-MG human glioblastoma and SW480 human colon cancer xenograft models. Here, DLL4 is linked to rheumatoid arthritis.