EGF and acne: Since IL1A is a key cytokine to modulate not only inflammation, but also follicular keratinocyte proliferation and abnormal differentiation, leading to comedogenesis, the initial step in the development of acne, which is missing in cetuximab-induced papulopustular eruptions (50), our results provide interesting start points for further studies to assess the role of EGF in the pathogenesis of diseases with follicular obstruction.