NLRP3 and acne: Importantly, despite the low number of the overlapping genes, the majority of the identified transcripts (such as CXCL8, IL1B, IL6, NLR family pyrin domain containing 3 [NLRP3] and PTGS2) are also pivotal in acne pathogenesis, suggesting that EGF- and PA-induced signaling in sebocytes may have a (patho)physiological relevance.