As shown in Table 3, multivariate logistic regression analysis indicated that CD4+ T-cells <68 cells/mm3 combined with CD8+ T-cells <111 cells/mm3 (OR 0.218, 95% CI 0.059–0.803, p=0.022), IL-6 >99 pg/mL combined with IL-10 >111 pg/mL (OR 17.614, 95% CI 2.319–133.769, p=0.006), and BNP level >500 pg/mL (OR 13.681, 95% CI 1.994–93.871, p=0.008) were independent risk factors for IPA in SFTS patients. The gene discussed is CD4; the disease is Ito hypomelanosis.