Thirty patients with IPA had lower levels of CD4+ and CD8+ lymphocytes and platelets (all p=0.000), higher levels of IL-6, TNF-α, IL-8 and IL-10 (all p=0.000), higher levels of G, GM, CRP, and APTT (all p<0.05), and a higher incidence of pancreatic and renal damage (p<0.05) compared with non-IPA patients. The gene discussed is CRP; the disease is Ito hypomelanosis.