Cut-off values of IL-6, TNF-α, IL-8, and IL-10 to predict IPA incidence in severe SFTS patients were 99 pg/mL, 63 pg/mL, 120 pg/mL, and 111 pg/mL (Table 2 and Figures 2, 3), with sensitivities of 90.0%, 86.7%, 83.3% and 90.0%, and specificities of 80.4%, 71.7%, 82.6% and 65.2%, respectively. Here, TNF is linked to Ito hypomelanosis.