Plasma hormones: cortisol and ACTH at 8 am, 4 pm, 12 am; IGF-1, LH, FSH, estradiol (women); testosterone, SHBG (men); prolactin, TSH, FT4Dynamic test according to results mainly- 8 am cortisol measurement after 1 mg dexamethasone test at 12 am (if suspicion of hypercortisolism)- OGTT with GH measurement in case of acromegaly suspicion- Intravenous insulin test with GH and cortisol measurement in case of suspicion of hypopituitarism (if no cardiac or neurological impairment). The gene discussed is GH1; the disease is acromegaly.