After adjusting for female age, body mass index, duration of infertility, type of infertility, cause of infertility, duration of stimulation, total FSH dosage, normal fertilization rate, number of embryos transferred, stage of transferred embryos, and endometrial thickness, a logistic regression analysis was performed to explore the independent association between early cumulus cell removal and pregnancy outcomes. This evidence concerns the gene BRD2 and Infertility.