IAPP and Beckwith-Wiedemann syndrome: This in turn leads to upregulation of miRNA targets such as IAPP and TP53INP1, that are associated with beta cell dysfunction and cell death, thus contributing to T2D pathogenesis (137).The significance of imprinting control in islet homeostasis and metabolic health is further emphasized by imprinting disorders such as the Beckwith-Wiedemann Syndrome (BWS) and Transient Neonatal Diabetes Mellitus (TNDM) [reviewed in (11)].