PARP1 and ischemia: When recombinant tissue plasminogen activator was given at 6 h of permanent ischemia, the degradation of tight junction proteins, the augmented tissue hemoglobin content, and the augmented sensorimotor deficits induced by recombinant tissue plasminogen activator were ameliorated by PJ34 treatment (100), implying that PARP inhibitors may be beneficial in those without successful recanalization.