Lastly, the reduced quality of life of patients with HCC correlated with the Child-Pugh score (used to describe and classify liver cirrhosis into different stages according to parameters of coagulation, bilirubin, albumin, ascites, and encephalopathy), the extent of restriction of the liver function and the occurrence of depressive symptoms (Mikoshiba et al., 2013). This evidence concerns the gene ALB and Encephalopathy.