Additionally, glial fibrillary acidic protein (GFAP), one of the astrocyte-specific biomarkers, is reduced in depression-associated brain regions including the prefrontal cortex, cingulate cortex (38, 39), hippocampus (40), amygdala (41), locus coeruleus (44), cerebellum (146), thalamus, and caudate nuclei (42). The gene discussed is GFAP; the disease is depressive disorder.