We focused on SNPs of some genes, related to impaired metabolism of neurotransmitter systems in schizophrenia and selected the non-synonymous polymorphisms of DRD3 (dopamine receptor type 3) rs6280, HTR1A (5-Hydroxytryptamine receptor type 1A) rs6295, BDNF (brain derived neurotrophic factor) rs6265 and 5HT2A (5-Hydroxytryptamine receptor type 2A) rs7322347 for further investigation. The gene discussed is BDNF; the disease is schizophrenia.