Studies have shown that the circulating level of IL-6 is positively correlated with the progression of DN in patients (Saraheimo et al., 2003), and IL-1β, IL-18, and IL-17A are associated with the occurrence and development of DN (Cortvrindt et al., 2017; Lemos et al., 2018; Lin et al., 2020a). Here, IL18 is linked to liver dysplastic nodule.