The overexpression of miR-199a-3p improves the injury in high glucose induced HK-2 cell damage model, following with decreased IL-1, IL-6 and TNF-α level, which is also consistent with the clinical finding that miR-199a-3p is negatively correlated with the progression of DN (Zhang et al., 2020b). This evidence concerns the gene IL1B and liver dysplastic nodule.