Therefore, we next investigated the effects of bortezomib on expression of cyclin D1, p-YAP, and YAP proteins and transcripts (Figures 2A,B, and Supplementary Figures S1, S2), cell viability (Figure 3A), colony formation (Figures 3C,D, and Supplementary Figures S3, S4), cell cycle (Figure 3E and Table 2), apoptosis (Figure 4 and Table 3), migration (Figure 5A), and invasiveness (Figures 5B,C) in three KIT-independent GIST cell lines (GIST48B, GIST54, and GIST226). The gene discussed is CCND1; the disease is gastrointestinal stromal tumor.