CD274 and cancer: Notably, clinical trials are ongoing for phase II/III in previously untreated metastatic melanoma, in combination with or without nivolumab (NCT03470922), phase II of nivolumab and oxaliplatin-based chemotherapy with or without relatlimab in GC or gastroesophageal junction (GEJ) cancer (NCT03662659), and phase II of relatlimab with nivolumab in mismatch repair deficient (dMMR) cancers resistant to prior PD-1/PD-L1 inhibition (Lipson et al., 2018; Feeney et al., 2019; Bever et al., 2020).