CD8A and hepatocellular carcinoma: CD8+ TILs isolated from tumors such as hepatocellular carcinoma (HCC), melanoma, ovarian cancer, and microsatellite instability high (MSI) colorectal cancer (CRC), have high levels of both PD-1 and LAG-3 (Matsuzaki et al., 2010; Li et al., 2013; Llosa et al., 2015; Taube et al., 2015).