TIM-3 is expressed in tumor cells and immune cells, such as helper T cells (Th1), IL-17-producing CD4+ effector cell lineage (Th17), CD8+ T cells, Tregs, TILs, and innate immune cells (Monney et al., 2002; Huang et al., 2010; Jan et al., 2011; Anderson, 2012). This evidence concerns the gene HAVCR2 and neoplasm.