PNLIP and metabolic disease: Up to now, several herbal medicines, such as Citri Reticulatae Pericarpium and Mori Radicis Cortex, have been demonstrated with strong inhibition on pancreatic lipase for the regulation of lipid metabolism, which are applied to treat hyperlipidemia and other metabolic diseases in clinic (Hou et al., 2018; Zeng et al., 2018).