Regulation in PPAR-γ, Insulin and p53-mediated signaling have been implicated in NAFLD development, whereas signatures of inflammatory signaling such as Toll-like receptor (TLR) and Nucleotide-binding, oligomerization domain (NOD) protein signaling pathways, in addition to pathways reflecting mitochondrial dysfunction characterize NASH (Figure 5) (Ryaboshapkina and Hammar, 2017). This evidence concerns the gene INS and metabolic dysfunction-associated steatohepatitis.