In parallel, Ji et al.(Ji et al., 2018) reported that the miR-327 expression was the highest in fibrotic heart tissue induced by transverse aortic constriction (TAC) in mice, and downregulation of miR-327 inhibited cardiac hypertrophy and fibrosis by targeting integrin β3(ITGB3). This evidence concerns the gene ITGB3 and cardiac hypertrophy.