VEGFA and insulin-resistant diabetes mellitus: Integrated system pharmacology and bioinformatics analysis revealed the Hub targets (including PPARG, RELA, EGFR, CASP3, VEGFA, AR, ESR1, and CCND1) and signaling pathways (including insulin signaling, endocrine resistance, TNF signaling, PI3K-Akt signaling, AMPK signaling, MAPK signaling, NF-κB signaling, HIF-1 signaling, apoptosis, and VEGF signaling pathways) involved in the underlying mechanisms of GQD in improving diabetic insulin resistance (Cao et al., 2020).