Compared to palliative platinum-based chemotherapy alone, the combined treatment with Xiaoaiping for 14 to 21 days in one chemotherapy cycle for 2-4 cycles showed beneficial effects on KPS scores (6 RCTs), improvement of white blood cell reduction (6 RCTs), and CD4 and CD4/CD8 level (3 RCTs) in IIIB-IV advanced lung cancer patients. This evidence concerns the gene CD4 and lung carcinoma.