Compared with chemotherapy alone, Kanglaite combined with chemotherapy showed significant effects on one-year survival rate (2 SRs), ORR (6 SRs), DCR (4 SRs), improved KPS scores (6 SRs), weight improvement (1 SR), nausea and vomiting (4 SRs), leukopenia (4 SRs), thrombopenia (3 SRs), anemia (1 SR), improvement on CD3 level (2 SRs), CD4 level (3 SRs), CD4/CD8 (2 SRs), and NK cells level (1 SR) in lung cancer patients. This evidence concerns the gene CD4 and anemia.