In terms of breast cancer (2 SRs), compared with chemotherapy alone, add-on with Shenqi Fuzheng injection showed beneficial effects on ORR, KPS scores, alopecia, liver and kidney function, leukopenia, thrombocytopenia, CD4, CD4/CD8, and abnormal changes in electrocardiogram in two SRs, and reducing cancer fatigue, nausea and vomiting, CD3, and NK cells level in one SR (Supplementary Table S2). The gene discussed is CD8A; the disease is cancer.