Compared with cisplatin based chemotherapy alone, Shenqi Fuzheng injection combined with NP (navelbine and cisplatin), GP (gemcitabine and cisplatin), and TP (paclitaxel and cisplatin) regimen showed beneficial effects on ORR (2 SRs), KPS scores (3 SRs), cancer fatigue (1 SR), cancer fever (2 SRs), leukopenia (3 SRs), thrombocytopenia (3 SRs), anemia (2 SRs), and immune function assessed by CD4, CD4/CD8, and NK cells level (2 SRs). This evidence concerns the gene CD8A and Decreased total leukocyte count.