CD4 and Decreased total leukocyte count: Compared with chemotherapy alone, add-on with Aidi injection showed significant effects on ORR (1 SR), DCR (1 SR), KPS scores (2 SRs), nausea and vomiting (1 SR), peripheral neurotoxicity (1 SR), diarrhea (1 SR), immune function (1 SR) assessed by CD3, CD4, CD4/CD8, and NK cells level, and leukopenia (2 SRs) in colorectal cancer patients.