CD4 and breast cancer: In terms of breast cancer (2 SRs), compared with chemotherapy alone, add-on with Shenqi Fuzheng injection showed beneficial effects on ORR, KPS scores, alopecia, liver and kidney function, leukopenia, thrombocytopenia, CD4, CD4/CD8, and abnormal changes in electrocardiogram in two SRs, and reducing cancer fatigue, nausea and vomiting, CD3, and NK cells level in one SR (Supplementary Table S2).