Besides, we also found that the treatments did not affect the expression of angiogenic markers in the HCC cells such as VEGF (Supplementary Figure S4) that is an important signaling molecule in vasculogenesis and angiogenesis, and CD31 (Supplementary Figure S4) that promotes HCC metastasis by inducing epithelial-mesenchymal transition. This evidence concerns the gene VEGFA and hepatocellular carcinoma.