PTTG1 and hepatocellular carcinoma: However, several limitations remain to be resolved in our future research: 1) whether FAD enhances chemosensitivity of the other drugs, such as oxaliplatin and 5-fluorouracil in HCC; 2) whether FAD displays a synergistic effect with those chemotherapeutic drugs in vivo; 3) the interaction between PTTG1 downregulation and DNA repair inhibition induced by FAD needs further exploration.