In addition, interaction of OST with BDNF may also contribute to OST’s ability to rescue the OVX-induced cognition deficit and alleviate depression-like behaviors since BDNF also plays a key role in cognition (Cunha et al., 2010) and in alleviating depression-like behaviors (Qiao et al., 2017). The gene discussed is BDNF; the disease is major depressive disorder.