EGCG induces apoptosis in cancer cells through different mechanisms, including the suppression of PI3K/Akt signaling (Liu et al., 2016), reduction in mitochondrial membrane potential (Li et al., 2009) and expression of anti-apoptotic proteins, including Bcl-2, xIAP, and Bcl-xl (Wu et al., 2009). This evidence concerns the gene BCL2 and cancer.