EGFR and non-small cell lung carcinoma: Indeed, HCC827 cells expressing constitutively active EGFR (EGFRmut) were more resistant to AcoA than CAL-12T (EGFRwt) cells (Figure 5C) and less susceptible to AcoA-induced apoptosis (Figure 5D), whereas the responsiveness to the conventional chemotherapeutic doxorubicin did not differ between EGFRwt and EGFRmut NSCLC cells (Figure 5C).