CRP and Cognitive impairment: Moreover, other population-based studies have demonstrated that dietary levels of fruit intake and vitamin C are inversely related to levels of C reactive protein (CRP), an inflammatory marker (Wannamethee et al., 2006) associated with age-related chronic diseases (Hulsegge et al., 2016), cognitive impairment (Gu et al., 2018; Lin et al., 2018), and frailty (Soysal et al., 2016).