These studies suggest that adiponectin may play a beneficial role in the anti-cognitive dysfunction of H2S. In the present study, we further found that neutralizing adiponectin by Anti-Acrp30 (Tian et al., 2018) attenuates the inhibitory effect of NaHS on CRS-induced cognitive impairment according to Y-maze test, NOR test, and MWM test. Here, ADIPOQ is linked to congenital rubella syndrome.