As shown in Figure 7, administration of NaHS (100 μmol/kg/day, i.p., for 4 weeks) obviously decreased the expressions of Bip (Figure 7A), Chop (Figure 7B) and Cleaved Caspase-12 (Figure 7C) in the hippocampus of CRS-exposed rats, while treatment with Anti-Acrp30 (1 μg/day, i.c.v., for 7 days) remarkably increased the expressions of Bip (Figure 7A), Chop (Figure 7B), and Cleaved Caspase-12 (Figure 7C) in the hippocampus of rats co-treated with NaHS and CRS, indicating that neutralizing adiponectin mitigates the inhibition of H2S on CRS-induced hippocampal ER stress. The gene discussed is HSPA5; the disease is congenital rubella syndrome.