In present study, our results further found that neutralizing adiponectin by Anti-Acrp30 abolishes the protection of NaHS against CRS-induced hippocampal apoptosis as evidenced by the increases in the amounts of pathological lesions in hippocampal neurons and the condensed and stained to yellowish-brown or brownish yellow neuron nucleuses under microscope (×400) and the expression of Bax as well as a decrease in the expression of Bcl-2. Here, ADIPOQ is linked to congenital rubella syndrome.