The results found that Anti-Acrp30 obviously increased the expressions of Bip, CHOP and Cleaved Caspase-12 in the hippocampus of rats cotreated with NaHS and CRS, which indicated that inhibition of adiponectin abolishes the protection of H2S against hippocampal ER stress in CRS rats. This evidence concerns the gene DDIT3 and congenital rubella syndrome.