The results found that Anti-Acrp30 obviously increased the expressions of Bip, CHOP and Cleaved Caspase-12 in the hippocampus of rats cotreated with NaHS and CRS, which indicated that inhibition of adiponectin abolishes the protection of H2S against hippocampal ER stress in CRS rats. Here, HSPA5 is linked to psychosocial stress measurement.