In the present work, we demonstrated that neutralizing adiponectin by Anti-Acrp30 not only blocks the protective effect of NaHS (an exogenous H2S donor) on CRS-induced cognitive impairment, but also reverses NaHS-induced the inhibition on hippocampal apoptosis, oxidative stress and ER stress in CRS-treated rats. This evidence concerns the gene ADIPOQ and congenital rubella syndrome.