In induced motor neurons (iMNs) derived from the iPSCs of C9-FTD/ALS patients, C9ORF72 localizes to Rab5-positive early endosomes, and neuronal death observed in patients’ iMNs was rescued when Rab5 activity was increased (Shi et al., 2018). This evidence concerns the gene RAB5A and amyotrophic lateral sclerosis.