OPTN and amyotrophic lateral sclerosis: Remarkably, there is considerable genetic evidence linking the autophagy/lysosomal pathway to FTD/ALS (Deng et al., 2017; Stamatakou et al., 2020), as proteins encoded by SQSTM1, OPTN, TBK1, VCP, UBQLN2, and CHMP2B, all genes involved in ALS and FTD, also function in this pathway.