C9orf72 and motor neuron disorder: Instead, reducing C9ORF72 to 40% with antisense oligonucleotide (ASO) resulted in an upregulation of the microglial activation genes in the spinal cord (Lagier-Tourenne et al., 2013), while C9orf72 KO mice predominantly developed an inflammatory phenotype, sometimes associated with a shortened life span, but no neurodegeneration or motor neuron disease (Koppers et al., 2015; Atanasio et al., 2016; Burberry et al., 2016; Jiang et al., 2016; O’Rourke et al., 2016; Sudria-Lopez et al., 2016; Sullivan et al., 2016; Ugolino et al., 2016).