Remarkably, there is considerable genetic evidence linking the autophagy/lysosomal pathway to FTD/ALS (Deng et al., 2017; Stamatakou et al., 2020), as proteins encoded by SQSTM1, OPTN, TBK1, VCP, UBQLN2, and CHMP2B, all genes involved in ALS and FTD, also function in this pathway. Here, OPTN is linked to frontotemporal dementia.