However, bacterial artificial chromosome (BAC) transgenic mice mainly reproduced RNA foci formation and DPR inclusions, whereas TDP-43 pathology, neurodegeneration, or FTD/ALS phenotypes were rare or inconstant (Peters et al., 2015; O’Rourke et al., 2016; Jiang et al., 2016; Liu Y. et al., 2016; Mordes et al., 2020; Nguyen et al., 2020). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.