In induced motor neurons (iMNs) derived from the iPSCs of C9-FTD/ALS patients, C9ORF72 localizes to Rab5-positive early endosomes, and neuronal death observed in patients’ iMNs was rescued when Rab5 activity was increased (Shi et al., 2018). Here, C9orf72 is linked to amyotrophic lateral sclerosis.