Interestingly, tau hyperphosphorylation and the related cognitive impairment have been reversed by BACE1 targeting in hippocampus, involving Hsc70 and LAMP2 proteins associated to autophagy-related mediated by chaperones (CMA) and increased mTOR activation (Piedrahita et al., 2016), also reducing arachidonic acid, cPLA2 and COX2 proinflammatory signals in vivo (Cardona-Gómez and Lopera, 2016). This evidence concerns the gene HSPA8 and Cognitive impairment.