The axonal tract defects identified in MAP6 KO mice correlate to a striking extent with anomalies identified on brain images from patients with schizophrenia (McCarley et al., 1999; De Peri et al., 2012; Shepherd et al., 2012; Bopp et al., 2017), including alteration of the fornix or of the cortico-spinal tract (Douaud et al., 2007; Kendi et al., 2008; Fitzsimmons et al., 2009; Luck et al., 2010; Davidson et al., 2012; Lee et al., 2013). Here, MAP6 is linked to schizophrenia.